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Study details
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Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer

National Cancer Institute (NCI)
NCT IDNCT01174121ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

332

Study length

about 19 years

Ages

18–72

Locations

1 site in MD

What this study is about

This trial is testing a new treatment that uses your own immune cells to fight cancer. The goal is to see if these TILs can shrink tumors and make the treatment safe.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive Young TIL
  • 2.Take Aldesleukin
  • 3.Take Cyclophosphamide
  • +2 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IVInjection / IV

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

aldesleukin, cyclophosphamide (Alkylating chemotherapy; crosslinks DNA strands), fludarabine, immunotherapy (PD-1 inhibitor immunotherapy (pembrolizumab)), pembrolizumab (Immune checkpoint inhibitor; blocks PD-1 to boost T-cell attack on cancer)

Drug routes

infusion

Endpoints

Primary: Response rate

Secondary: Frequency and severity of treatment-related adverse events

Body systems

Endocrinology, Oncology