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Study details
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Cladribine, Idarubicin, Cytarabine, and Venetoclax Trial

M.D. Anderson Cancer Center
NCT IDNCT02115295ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

508

Study length

about 16 years

Ages

18–65

Locations

1 site in TX

What this study is about

This trial is testing a treatment with cladribine, idarubicin, cytarabine, and venetoclax for people with acute myeloid leukemia, high-risk myelodysplastic syndrome, or blastic phase chronic myeloid leukemia. The goal of this treatment is to stop the growth of cancer cells.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Laboratory Biomarker Analysis
  • 2.Take Cladribine
  • 3.Take Cytarabine
  • +3 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IVInjection / IV

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

cladribine, cytarabine, gilteritinib, idarubicin, midostaurin, venetoclax

Drug routes

injection, intravenous, injection (Injection), oral (Oral Tablet), oral (Oral Capsule), oral

Endpoints

Primary: Complete response (CR) rate

Secondary: Duration of response, Event-free survival (EFS), Incidence of toxicities, Overall response rate (ORR), Overall survival (OS)

Body systems

Oncology, Musculoskeletal