Arginine Therapy for Pain in Children with Sickle Cell Disease
Phase 1/2
21
about 11 years
7–21
2 sites in GA
What this study is about
This trial is testing whether giving extra arginine to children with sickle cell disease will reduce pain, decrease the need for pain medication, or shorten hospital stays. It involves different ways of administering arginine.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Take Arginine
- 2.Take Arginine (Continuous)
- 3.Take Arginine (Loading)
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
You are randomly assigned, but you will know your treatment.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
Therapeutic Nutrients/Minerals/Electrolytes (Biological Macromolecular Activity)
oral (Oral Capsule)
Primary: Pharmacokinetics of IV arginine, measured by plasma arginine concentration over time
Secondary: Apparent clearance of arginine, Area Under the Plasma Concentration -Time Curve (AUC) From Time 0 to the Time of the Last Quantifiable Concentration for Arginine, Terminal elimination half-life (t1/2) for arginine