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Study details
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Non-invasive Ventilation to Reduce Intubation Needs

M.D. Anderson Cancer Center
NCT IDNCT02464696ClinicalTrials.gov data as of Apr 2026
Target enrollment

256

Study length

about 11 years

Ages

18+

Locations

1 site in TX

What this study is about

This trial is testing if non-invasive ventilation helps reduce the need for intubation in people with cancer and respiratory failure. Respiratory failure means not enough oxygen gets into the blood, which is common in patients with hematological and solid tumor diseases. Non-invasive positive pressure ventilation (NIPPV) uses a mask to deliver oxygen. It compares NIPPV to standard high flow oxygen to see if it improves oxygen levels, reduces shortness of breath, and lowers the need for intubation.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Methylprednisolone
  • 2.Undergo Oxygen Therapy
  • 3.Use Positive Air Pressure Device

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IV

How treatment is administered

Treatment Assignment
Randomized (Open Label)

You are randomly assigned, but you will know your treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

methylprednisolone, VARIOUS

Drug routes

injection (Injection)

Endpoints

Secondary: Hospital length of stay, Intensive care unit length of stay

Body systems

Oncology