Radiation Therapy Trial
Phase 2
189
about 11 years
18+
640 sites in AK, AL, AR +44
What this study is about
This trial is testing whether radiation therapy, alone or with cisplatin, is effective for people who have had surgery for squamous cell carcinoma of the head and neck. Radiation uses high-energy x-rays to kill cancer cells. Cisplatin is a chemotherapy drug that works in different ways to stop tumor growth.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Laboratory Biomarker Analysis
- 2.Receive Intensity-Modulated Radiation Therapy
- 3.Take Cisplatin
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
You are randomly assigned, but you will know your treatment.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
cisplatin (Platinum chemotherapy; crosslinks DNA to stop replication)
injection, intravenous
Primary: Disease-free survival in patients with stage III-IV disease and disruptive p53 mutation
Secondary: Disease-free survival in patients with stage III-IV disease and non-disruptive p53 mutation, Disease-free survival in patients with stage III-IV disease and wild type p53 mutation, Incidence of adverse events graded using Common Terminology Criteria for Adverse Events version 4, p53 as a predictive marker of recurrence
radiation
Oncology