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Study details
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Dynamic Contrast-Enhanced MRI for Diagnosing Osteoradionecrosis

M.D. Anderson Cancer Center
NCT IDNCT03145077ClinicalTrials.gov data as of Apr 2026
Target enrollment

1,400

Study length

about 10 years

Ages

18+

Locations

1 site in TX

What this study is about

This trial is testing if dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can help doctors diagnose osteoradionecrosis in people with head and neck cancer who are receiving radiation therapy. DCE-MRI may assist doctors to predict osteoradionecrosis in patients with head and neck cancer undergoing radiation therapy.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Questionnaire Administration
  • 2.Undergo Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: DCE-MRI Derived Parameters Following External Beam Radiation Therapy (EBRT) and Subsequent Development of Osteoradionecrosis (ORN)

Secondary: Dose-Response Relationships Between DCE-MRI Derived Imaging Biomarkers and Subsequent Development of Osteoradionecrosis (ORN)

Procedures

imaging

Body systems

Oncology