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Study details
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IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy

David Ware Branch
NCT IDNCT03152058ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

55

Study length

about 9.6 years

Ages

18–40

Sex

Female only

Locations

2 sites in NY, UT

What this study is about

Researchers are testing if adding certolizumab, an anti-tumor necrosis factor-alpha drug, to usual treatment (heparin and aspirin) improves pregnancy outcomes for women with antiphospholipid syndrome (APS) who have repeatedly positive tests for lupus anticoagulant (LAC). The goal is to enroll 55 women. The trial will last approximately 3515 days.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Certolizumab Pegol

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IV

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

certolizumab pegol

Drug routes

injection (Injection)

Body systems

Reproductive Health, Immune