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Study details
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Gene Transfer Trial for Cancer

National Cancer Institute (NCI)
NCT IDNCT03190941ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

110

Study length

about 11 years

Ages

18–72

Locations

1 site in MD

What this study is about

This trial is testing a new treatment that involves taking white blood cells from your body, modifying them in the lab with a special gene, and then returning them to you. The goal is to determine if this modified cell therapy is safe and can shrink tumors in people with certain types of cancer.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive Anti-KRAS G12V mTCR PBL
  • 2.Take Aldesleukin
  • 3.Take Cyclophosphamide
  • +1 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IV

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

aldesleukin, cyclophosphamide (Alkylating chemotherapy; crosslinks DNA strands), fludarabine

Drug routes

infusion

Endpoints

Primary: Frequency and severity of treatment-related adverse events, Response rate

Body systems

Oncology