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Study details
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Nivolumab Trial

National Cancer Institute (NCI)
NCT IDNCT03258567ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

40

Study length

about 13 years

Ages

12+

Locations

1 site in MD

What this study is about

Researchers are testing if Nivolumab can slow the growth of certain cancers, specifically Epstein-Barr Virus (EBV)-positive lymphoproliferative disorders and EBV-positive non-Hodgkin lymphomas. The trial will evaluate the safety of this treatment in adults and children with these conditions who have not responded to other therapies.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive Nivolumab

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IV

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

nivolumab (Immune checkpoint inhibitor; blocks PD-1 receptor on T cells)

Drug routes

infusion

Endpoints

Primary: overall response rate of nivolumab in patients with EBV-positive LPD and EBV-positive NHL

Secondary: PFS of patients with EBV-LPD treated with nivolumab, overall survival of patients with EBV-LPD treated with nivolumab, toxicity profile of nivolumab in patients with EBV-LPD

Body systems

Oncology