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Study details
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A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

Global Coalition for Adaptive Research
NCT IDNCT03970447ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2/3

Target enrollment

1,280

Study length

about 11 years

Ages

18+

Locations

42 sites in AL, CA, CO +19

What this study is about

Researchers are testing different treatments for newly diagnosed or recurring glioblastoma. The trial will evaluate several therapies, including drugs, radiation, and other approaches, across a large group of patients.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive ADI-PEG 20
  • 2.Receive Radiation
  • 3.Take AZD1390
  • +3 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
OralOral

How treatment is administered

Treatment Assignment
Randomized (Open Label)

You are randomly assigned, but you will know your treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

lomustine, pi3k inhibitor, regorafenib, temozolomide

Drug routes

oral, oral (Oral Tablet), injection, intravenous

Endpoints

Primary: Overall Survival (OS)

Secondary: Duration of Response (CR + PR), Progression-free survival (PFS), Tumor Response

Procedures

radiation

Body systems

Oncology