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Study details
Enrolling now

Ocrelizumab for Psychosis by Autoimmunity

The Methodist Hospital Research Institute
NCT IDNCT03971487ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

40

Study length

about 6.1 years

Ages

18–35

Locations

1 site in TX

What this study is about

This trial is testing whether ocrelizumab, a medication that suppresses auto-antibodies, can help people with psychosis caused by autoimmune factors. Participants will receive ocrelizumab infusions and undergo evaluations to assess the treatment's effects on their symptoms and cognitive function. It aims to determine if this approach is effective in managing psychosis related to auto-antibody production.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Participate in Physical and neuro-cognitive evaluations
  • 2.Participate in Psychosis and cognitive assessments
  • 3.Receive Ocrelizumab infusion
  • +1 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IVInjection / IV

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

ocrelizumab

Drug routes

injection, intravenous, infusion

Endpoints

Secondary: Score on quality of life scales for psychiatric patients

Procedures

diagnostic

Body systems

Psychiatry / Mental Health