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Study details
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Hypofractionated Accelerated Pelvic Nodal Radiotherapy (GCC 2048)

University of Maryland, Baltimore
NCT IDNCT04486755ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

18

Study length

about 6.8 years

Ages

18+

Sex

Male only

Locations

1 site in MD

What this study is about

This trial is testing the safety of delivering three shorter radiation schedules to the pelvic area and prostate. The goal is to see if this approach can safely deliver more radiation over a longer period while minimizing damage to healthy tissues.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive Hypofractionated Radiation Therapy

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: HypoFx RT schedule that results in <33% acute dose-limiting toxicity with accelerated, HypoFx pelvic nodal RT

Secondary: Evaluate the duration of biochemical progression-free survival, Frequency of acute and late GI, GU, hematologic, and neurologic toxicity for each dose cohort, Patient Reported Outcomes (PROs) related to urinary and bowel function, Patient Reported Outcomes (PROs) related to urinary function

Procedures

radiation

Body systems

Oncology