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Study details
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Duloxetine and Neurofeedback Training for Chemotherapy-Induced Peripheral Neuropathy

M.D. Anderson Cancer Center
NCT IDNCT04560673ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

380

Study length

about 6.5 years

Ages

18+

Locations

2 sites in TX

What this study is about

This trial is testing whether duloxetine and neurofeedback training are effective in treating chemotherapy-induced peripheral neuropathy. Duloxetine is a medication that increases certain brain chemicals to help relieve depression and peripheral neuropathy. Neurofeedback training uses an EEG to measure brain wave activity and may teach patients with peripheral neuropathy how to change their brain waves to lower feelings of neuropathy and improve quality of life.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Participate in Neurofeedback
  • 2.Quality-of-Life Assessment
  • 3.Questionnaire Administration
  • +1 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Oral

How treatment is administered

Treatment Assignment
Randomized (Open Label)

You are randomly assigned, but you will know your treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

duloxetine (SNRI; increases serotonin and norepinephrine levels)

Drug routes

oral (Delayed Release Oral Capsule)

Endpoints

Primary: Change in Pain Quality Assessment Scale (PQAS) unpleasantness score

Secondary: Change in cancer-related symptoms, Change in quality of life, Evaluation of patients who will require more sessions of NFB to achieve relief of symptoms

Procedures

monitoring

Body systems

Oncology