Hypoxia Imaging for Esophageal Cancer to Guide Personalized Radiation Therapy
Phase 1
16
about 5.6 years
18+
1 site in UT
What this study is about
Researchers are testing a new way to treat esophageal cancer by using imaging to identify areas of low oxygen (hypoxia) in the tumor. The goal is to give higher doses of radiation only to those tumors that are hypoxic, while standard treatment is used for non-hypoxic tumors. The trial will evaluate the safety of this personalized approach.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Receive Radiation
- 2.Take FMISO PET CT
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
Everyone gets the investigational treatment.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
Primary: frequency of adverse events (AEs) and serious adverse events (SAEs) characterized by type, severity (as defined by the NIH CTCAE, version 5.0), seriousness, duration, and relationship to study treatment, rate of grade ≥ 4 esophageal adverse events attributed to radiation therapy that occur within 30 days of finishing radiation therapy, rate of grade ≥ 4 esophageal adverse events attributed to radiation therapy that occur within 84 days of finishing radiation therapy
Secondary: Progression-free survival (PFS)
radiation