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Study details
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Reducing Opioid Mortality in Illinois

University of Chicago
NCT IDNCT04925427ClinicalTrials.gov data as of Apr 2026
Target enrollment

1,500

Study length

about 5.1 years

Ages

18+

Locations

5 sites in IL

What this study is about

This trial is testing two ways to help people who have used opioids and are released from jail or prison. One way is case management with peer recovery support, and the other is giving naloxone (an opioid overdose reversal drug) only. The goal is to see which approach works best at reducing deaths related to opioid use.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Participate in Case Management and Peer Recovery
  • 2.Participate in Naloxone-Only

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized (Open Label)

You are randomly assigned, but you will know your treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

opioid antagonist (Opioid antagonist; blocks opioid receptors)

Endpoints

Secondary: All-cause mortality, Opioid Use Disorder (OUD) Symptoms, Patient Reported Outcomes Measurement Information System, Social cost of re-arrest and associated offenses, Social cost of self reported crime, Stimulant Use Disorder Symptoms

Body systems

Psychiatry / Mental Health