COAST Therapy in Advanced Solid Tumors and Prostate Cancer
Phase 1/2
76
about 5.2 years
18+
1 site in SC
What this study is about
Researchers are testing a combination of drugs to treat advanced solid tumors and prostate cancer. The trial will evaluate the safety and effectiveness of up to 5 different medications, including hydroxychloroquine, metformin, sirolimus, dasatinib, and nelfinavir, given orally.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Take Hydroxychloroquine, Metformin, Sirolimus
- 2.Take Hydroxychloroquine, Metformin, Sirolimus, Dasatanib
- 3.Take Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir
- +1 more
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
Everyone gets the investigational treatment.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
kinase inhibitor, dasatinib, hydroxychloroquine (Antimalarial; increases pH in parasite), antimalarial (Antimalarial; increases pH in parasite), metformin (Biguanide antidiabetic; reduces liver glucose production and improves insulin sensitivity), nelfinavir, sirolimus
oral (Oral Tablet), oral, injection, intravenous
Primary: Maximum Tolerated Dose (MTD) - Phase I
Secondary: Change in Quality of Life (QOL) score
Oncology