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Study details
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Intraoperative Radiation Therapy After Stereotactic Body Radiation Therapy and Chemotherapy in Treatment of Pancreatic Adenocarcinoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT IDNCT05141513ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

25

Study length

about 6 years

Ages

18+

Locations

1 site in MD

What this study is about

This trial is testing the safety of intraoperative radiation therapy (IORT) after stereotactic body radiation therapy (SBRT) and chemotherapy for people with pancreatic cancer who are having surgery. The treatment involves using a high dose rate brachytherapy technique during surgery.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive High Dose Rate Brachytherapy (HDR) Intraoperative Radiation Therapy (IORT)

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: Acute post-operative toxicity of targeted IORT

Secondary: Late post-operative toxicity of targeted IORT, Median local-progression free survival (LPFS) from IORT, Median overall survival (OS) from IORT, Median progression free survival (PFS) from IORT

Procedures

radiation

Body systems

Oncology