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Study details
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SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

Mayo Clinic
NCT IDNCT05222620ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

69

Study length

about 5.9 years

Ages

18+

Locations

7 sites in AZ, FL, MN +1

What this study is about

This trial is testing whether single fraction stereotactic radiosurgery (SRS) is better than fractionated stereotactic radiosurgery (FSRS) in treating brain tumors that have spread from other parts of the body. The goal is to see if one dose of radiation is as effective as multiple doses for controlling tumor growth and minimizing side effects.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Questionnaire Administration
  • 2.Receive Stereotactic Radiosurgery
  • 3.Undergo Magnetic Resonance Imaging

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized (Open Label)

You are randomly assigned, but you will know your treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Secondary: Incidence of adverse events, Overall survival (OS), Quality of life (QOL)

Procedures

imaging, radiation