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Study details
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Abatacept in Immune Checkpoint Inhibitor Myocarditis Trial

Massachusetts General Hospital
NCT IDNCT05335928ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

390

Study length

about 4.8 years

Ages

18+

Locations

29 sites in CA, DC, FL +18

What this study is about

This trial is testing whether abatacept, as compared to placebo, reduces major adverse cardiac events (MACE) in adults hospitalized with myocarditis caused by immune checkpoint inhibitors. MACE includes cardiovascular death, sudden cardiac arrest, cardiogenic shock, significant arrhythmias, or incident heart failure.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Abatacept plus
  • 2.Take Placebo

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IVInjection / IV

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

abatacept

Drug routes

injection, intravenous

Endpoints

Primary: Major adverse cardiac events

Secondary: Other immune-related adverse events between the two groups

Body systems

Oncology