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Study details
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An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) for Brain Metastasis in HER2+ Breast Cancer

City of Hope Medical Center
NCT IDNCT05376878ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

10

Study length

about 3.2 years

Ages

18+

Locations

1 site in CA

What this study is about

This trial is testing an investigational scan called 64Cu-DOTA-trastuzumab PET/MRI to see if it can help find HER2+ breast cancer that has spread to the brain. The scan may also show whether the cancer cells take up trastuzumab, which could predict how well they will respond to a standard chemotherapy drug.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Copper Cu 64-DOTA-Trastuzumab
  • 2.Receive Trastuzumab
  • 3.Receive Trastuzumab Deruxtecan
  • +2 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IVInjection / IV

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

trastuzumab (Monoclonal antibody; targets HER2 protein on cancer cells), trastuzumab deruxtecan

Drug routes

injection, intravenous, infusion

Endpoints

Secondary: Progression-free Survival

Procedures

imaging