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Study details
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Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

University of California, Los Angeles
NCT IDNCT05417555ClinicalTrials.gov data as of Apr 2026
Target enrollment

144

Study length

about 3.9 years

Ages

50–90

Locations

1 site in CA

What this study is about

Researchers are testing whether Low Intensity Focused Ultrasound Pulsation (LIFUP) can improve memory in people with Mild Cognitive Impairment and Mild Alzheimer's Disease. The trial will measure brain activity using MRIs and assess memory function through tests, while participants receive LIFUP treatment to a specific area of the brain involved in memory.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Use Low-Intensity Focused Ultrasound Pulsation (LIFUP)

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Secondary: Post-hoc biomarker analysis of APOE-4 status as a predictor of tFUS efficacy, Post-hoc biomarker analysis of plasma AB42/40 ratio as a predictor of tFUS efficacy, Post-hoc biomarker analysis of plasma ptau as a predictor of tFUS efficacy

Body systems

Neurology