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Study details
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Safety and Efficacy of Expanded, Universal Donor Natural Killer Cells for Relapsed/Refractory AML

Nationwide Children's Hospital
NCT IDNCT05503134ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

20

Study length

about 5 years

Ages

1–24

Locations

1 site in OH

What this study is about

This trial is testing the safety and effectiveness of a treatment using universal donor natural killer cells in people with relapsed or refractory acute myeloid leukemia (AML). The goal is to determine the best dose of this treatment.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive Universal Donor Natural Killer Cells

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: Incidence and severity of adverse events

Secondary: CR rate after first cycle, Minimal Residual Disease (MRD) negative response rate by flow cytometry, Relapse free survival and overall survival

Body systems

Oncology