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Study details
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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

Chris Goss
NCT IDNCT05548283ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

730

Study length

about 3.6 years

Ages

6+

Locations

59 sites in AL, AZ, CA +29

What this study is about

This trial is testing whether a single aminoglycoside antibiotic, combined with a beta-lactam antibiotic, is as effective as two different antibiotics (tobramycin and a beta-lactam) in treating pulmonary exacerbations in people with cystic fibrosis. The goal is to determine if using one type of antibiotic provides the same improvement in lung function and symptoms compared to using two types.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Aminoglycoside
  • 2.Take Beta-lactam antibiotic

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized (Open Label)

You are randomly assigned, but you will know your treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

antibiotic

Endpoints

Primary: Absolute Change in FEV1 % Predicted at Week 4 in Aminoglycoside (AG) Study, Incidence of Adverse Events (AEs) in Aminoglycoside (AG) Study Intervention Arms

Body systems

Respiratory