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Study details
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Intermittent Hypoxia-initiated Plasticity in Humans

VA Office of Research and Development
NCT IDNCT05558501ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

60

Study length

about 5 years

Ages

30–60

Locations

1 site in MI

What this study is about

This trial is testing a new treatment called Mild Intermittent Hypoxia (MIH) to see if it can help people with sleep apnea and related health problems. The goal is to determine if repeated exposure to mild intermittent hypoxia reduces heart and blood vessel dysfunction, tiredness/fatigue experienced while exercise performance, and improves upper airway stability and sleep quality.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Mild Intermittent Hypoxia
  • 2.Sham MIH

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: Change in Blood Pressure

Secondary: Change in Sympatho-Vagal Balance (Blood Pressure Variability), Change in Sympatho-Vagal Balance (Heart Rate Variability)