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Study details
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Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy

Massachusetts Institute of Technology
NCT IDNCT05655195ClinicalTrials.gov data as of Apr 2026
Target enrollment

50

Study length

about 3.7 years

Ages

65–100

Locations

1 site in MA

What this study is about

This trial is testing whether using a light and sound device at home can help people with mild Alzheimer's disease. The device stimulates the brain to boost gamma waves, which may reduce harmful proteins in the brain and improve memory. Participants will use the device daily for 6 months and undergo various tests to measure changes in their brains and cognitive function.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Use GENUS device (Active Settings)
  • 2.Use GENUS device (sham settings)

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: Baseline incidence of stimulation-related adverse symptoms and side effects as assessed by post-stimulation questionnaires, Change in stimulation-related adverse symptoms and side effects as assessed by post-stimulation questionnaires, Changes in functional brain connectivity as measured by changes in blood-oxygen-level-dependent (BOLD) signals on functional MRI scans, Changes in functional brain connectivity as measured by changes in brain white matter on functional MRI scans, Endpoint incidence of stimulation-related adverse symptoms and side effects as assessed by post-stimulation questionnaires, Mid-point incidence of stimulation-related adverse symptoms and side effects as assessed by post-stimulation questionnaires

Body systems

Neurology