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Study details
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Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease

Johns Hopkins University
NCT IDNCT05795634ClinicalTrials.gov data as of Apr 2026
Target enrollment

240

Study length

about 6 years

Ages

60+

Locations

1 site in MD

What this study is about

This trial is testing how stress affects memory and thinking skills in people who are likely to develop Alzheimer's disease. It looks at hormone responses to stress, genes that increase Alzheimer's risk, and how these factors relate to cognitive decline over time. Participants will have blood and saliva tests, take a stress test, complete questionnaires, and undergo memory and thinking skill assessments.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Participate in Trier Social Stress Test

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Procedures

diagnostic

Body systems

Neurology