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Study details
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Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery

Loyola University
NCT IDNCT05824832ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

120

Study length

about 3.3 years

Ages

18+

Locations

1 site in IL

What this study is about

Researchers are testing if adding buprenorphine, clonidine, and dexamethasone to interscalene brachial plexus blocks reduces the need for morphine after upper extremity surgery. The trial will last 1218 days and involve approximately 120 adults.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Interscalene block with buprenorphine alone
  • 2.Take Interscalene block with the addition of buprenorphine, clonidine, dexamethasone

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
sublingualInjection / IV

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

opioid partial agonist (Partial opioid agonist; relieves pain and treats opioid dependence), clonidine, dexamethasone, corticosteroid (Glucocorticoid; potent anti-inflammatory and immunosuppressant)

Drug routes

sublingual, injection, ocular

Endpoints

Secondary: Pain reported via a numeric rating scale (NRS)