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Study details
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Image-Based Assessment of Tumor Hypoxia for Radiation Therapy

Vanderbilt-Ingram Cancer Center
NCT IDNCT05996432ClinicalTrials.gov data as of Apr 2026
Phase

EARLY_PHASE1

Target enrollment

48

Study length

about 6 years

Ages

18+

Locations

1 site in TN

What this study is about

This trial is testing a new way to assess how much oxygen tumors need. The goal is to see if this information can help doctors choose the best radiation treatment plan. This will involve using imaging techniques like MRI and PET scans.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take 18F-fluoromisonidazole
  • 2.Undergo Magnetic Resonance Imaging (MRI)
  • 3.Undergo Positron Emission Tomography (PET)

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

antifungal

Endpoints

Primary: Validate non-invasive, MRI-based markers of tumor hypoxia in patients with brain metastases or head and neck cancer with and without evidence of tumor hypoxia identified by 18F-FMISO-PET-CT

Secondary: Assess treatment-related changes in tumor and peritumoral tissue oxygen consumption and perfusion via non-invasive MRI

Procedures

imaging

Body systems

Oncology