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Study details
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Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

Johns Hopkins University
NCT IDNCT06067737ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

90

Study length

about 5.3 years

Ages

21–70

Locations

1 site in MD

What this study is about

This trial is testing whether psilocybin can help people with opioid use disorder (OUD) stay sober and improve their lives when used alongside buprenorphine treatment. Participants will receive either a high dose or a low dose of psilocybin as an addition to standard outpatient buprenorphine care, and it will last for 1939 days.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Psilocybin

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Oral

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug routes

oral

Endpoints

Secondary: Depression as assessed by the Beck Depression Inventory II (BDII), Quality of Life as assessed by the World Health Organization Quality of Life Brief Version (WHOQOL-BREF)

Body systems

Psychiatry / Mental Health