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Study details
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Phase 2 Trial of Flexible Dosing Schedule of 177Lu-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer

Jonsson Comprehensive Cancer Center
NCT IDNCT06216249ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

90

Study length

about 4.4 years

Ages

18+

Sex

Male only

Locations

1 site in CA

What this study is about

This trial is testing a flexible dosing schedule of the drug 177Lu-PSMA-617 for men with advanced prostate cancer that has not responded to other treatments. It compares this flexible approach to a standard, fixed dosing schedule. The goal is to see if patients can benefit from more treatment cycles than originally planned.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Gallium Ga 68 Gozetotide
  • 2.Questionnaire Administration
  • 3.Take Lutetium Lu 177 Vipivotide Tetraxetan
  • +3 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized (Open Label)

You are randomly assigned, but you will know your treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

gallium (68Ga) gozetotide, lutetium (177Lu) vipivotide tetraxetan

Endpoints

Secondary: Bone pain level, DCR by combined radiographic + PSA response, Disease control rate (DCR), Health related quality of life (major symptoms/toxicities), Health related quality of life (pain), Incidence of adverse events, Overall survival, Performance status

Procedures

imaging