Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment
Phase 3
710
about 9 years
18+
Male only
46 sites in CA, IL, MO +4
What this study is about
This trial is testing whether a new way of giving radiation therapy, called SBRT, is as effective as usual radiation therapy for prostate cancer. The treatment involves suppressing testosterone levels with medication (ADT) along with radiation therapy and brachytherapy.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Receive Radiation
- 2.Receive Radiation SBRT only
- 3.Take ADT
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
You are randomly assigned, but you will know your treatment.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
hormone therapy
Primary: To compare the progression-free survival (PFS) of SBRT versus conventional EBRT plus brachytherapy boost defined as time to biochemical failure, initiation of salvage therapy, local-regional recurrence, distant progression, or death
Secondary: Economic Outcomes using EQ-5D-5L, Economic Outcomes using FACIT-COST, Overall Survival analysed using a Cox proportional hazards model and graphically described using the Kaplan-Meier method, Participant-reported tolerability using PRO-CTCAE questionnaire, Safety and tolerability assessed by CTCAE v5.0
radiation
Oncology