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Study details
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FDG-PET-Guided Metastasis Directed Radiation Therapy for the Treatment of Metastatic Hormone Sensitive Prostate Cancer, The PRTY Trial

Northwestern University
NCT IDNCT06244004ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

125

Study length

about 4 years

Ages

18+

Sex

Male only

Locations

6 sites in IL

What this study is about

This trial is testing whether FDG-PET-guided metastasis directed radiation therapy (MDRT) combined with standard treatments works better than standard treatments alone in treating metastatic hormone sensitive prostate cancer. This treatment approach aims to target active cancer sites identified through FDG-PET scans.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive Radiation Therapy
  • 2.Take Antiandrogen Therapy
  • 3.Take Cytotoxic Chemotherapy
  • +3 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized (Open Label)

You are randomly assigned, but you will know your treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: Complete response rate (Cohort 2), Progression free survival (PFS) (Cohort 1)

Secondary: Incidence of AEs of MDRT (Cohort 2), Incidence of adverse events (AEs) of metastasis directed radiation therapy (MDRT) (Cohort 1), Objective response rate (Cohort 2), PFS (Cohort 2), Radiographic PFS (rPFS) (Cohort 1)

Procedures

imaging, radiation