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Study details
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Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

University of North Carolina, Chapel Hill
NCT IDNCT06263452ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

120

Study length

about 2.1 years

Ages

18–30

Locations

1 site in NC

What this study is about

This trial is testing if a beta-blocker can change how your body reacts to stress, specifically in terms of inflammation and nerve activity. The goal is to understand these changes better so that new treatments for heart disease can be developed.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Placebo
  • 2.Take Propranolol

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

propranolol (Non-selective beta blocker; slows heart rate)

Endpoints

Primary: Change in levels of inflammatory gene expression in response to social stress, Change in levels of pro-inflammatory cytokine interleukin-6 in response to social stress

Body systems

Cardiology / Heart