Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury
EARLY_PHASE1
16
about 1.8 years
18+
2 sites in MS
What this study is about
This trial is testing whether transcutaneous spinal stimulation can improve muscle stiffness and spasms after a spinal cord injury. It compares different levels of spinal stimulation, as well as combining it with medications like baclofen or tizanidine, to see which approach works best for reducing these symptoms.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Take Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen
- 2.Take Transcutaneous spinal stimulation at 50 Hz and single dose of tizanidine
- 3.Use Sham transcutaneous spinal stimulation
- +2 more
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
Assignment is predetermined by the study protocol.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
MUSCULO-SKELETAL SYSTEM
oral (Oral Tablet), oral (Oral Capsule)
Primary: Change from baseline in muscle stiffness as measured by the Modified Ashworth Scale (MAS),, Change from baseline in spasms as measured by the Spinal Cord Assessment Tool for Spastic Reflexes (SCATS)., Change from baseline of flexion withdrawal reflex (FWR) response amplitude., Change from baseline of posterior root reflexes (PRRs) recruitment curves., Change from baseline of stretch reflex (SR) response amplitude.
Secondary: Change from baseline of flexion withdrawal reflex (FWR) response amplitude., Change from baseline of posterior root reflexes (PRRs) recruitment curves., Change from baseline of stretch reflex (SR) response amplitude.
therapeutic
Neurology