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Study details
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Interstitial Photodynamic Therapy Following Palliative Radiotherapy in Treating Patients With Inoperable Malignant Central Airway Obstruction

Roswell Park Cancer Institute
NCT IDNCT06306638ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

53

Study length

about 5 years

Ages

18+

Locations

2 sites in NY, PA

What this study is about

This trial is testing the safety and effectiveness of interstitial photodynamic therapy after palliative radiation for patients with tumors blocking their airway. The goal is to see if PDT can help shrink or control these tumors without causing as much harm as high-dose radiotherapy.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Physical Performance Testing
  • 2.Questionnaire Administration
  • 3.Receive Palliative Radiation Therapy
  • +3 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IVInjection / IV

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

verteporfin

Drug routes

injection, intravenous

Endpoints

Primary: Incidence of >= grade 3 adverse events (Phase I)

Secondary: Progression free survival (Phase I and II), Quality of life (Phase I and II)

Procedures

diagnostic, imaging, radiation

Devices

therapeutic

Body systems

Oncology