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Study details
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Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain

University of South Florida
NCT IDNCT06345872ClinicalTrials.gov data as of Apr 2026
Target enrollment

165

Study length

about 3.6 years

Ages

18+

Locations

1 site in FL

What this study is about

This trial is testing two behavioral interventions for chronic insomnia in individuals with chronic pain. The goal is to see if improving sleep and decreasing arousal leads to normalized brain activation and reduced opioid use.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Participate in CBT-I
  • 2.Participate in Treatment as usual
  • 3.Tapered Withdrawal

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: Change in Fatigue - Daily Electronic Sleep Diaries, Change in Insomnia Severity Index, Change in Neural Imaging: Structural/Functional MRI/Diffusion Weighted Imaging, Change in Pain Intensity - Daily Electronic Sleep Diaries, Change in Perceived Stress Scale, Change in Sleep and Pain Medication - Daily Electronic Sleep Diaries, Change in Thermal Pain Response

Secondary: Change in Neural Connectivity: Structural/Functional MRI/Diffusion Weighted Imaging, Change in Pain Catastrophizing Scale

Body systems

Psychiatry / Mental Health