Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use

Researchers are testing if a new way to start buprenorphine, called rapid outpatient low-dose initiation (ROLDI), can be safer and more effective than the usual method for people with opioid use disorder who also use fentanyl. ROLDI involves starting with very small doses of buprenorphine without requiring or causing withdrawal. The trial will also look at how fentanyl levels change in the body during early abstinence to understand why some people experience precipitated withdrawal when starting standard buprenorphine treatment.

Simplified from trial records by PatientMatch.

What you may be asked to do

• 1.Take Buprenorphine