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Study details
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A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

NaviFUS Corporation
NCT IDNCT06388707ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

8

Study length

about 1.3 years

Ages

18+

Locations

3 sites in CA, MA, VA

What this study is about

This trial is testing the safety, tolerability, and early effectiveness of low-intensity focused ultrasound neuromodulation using a device called NaviFUS System in people with drug-resistant epilepsy. The treatment will be given for 474 days.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Use NaviFUS System

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: Adverse events (AEs)

Secondary: Change from baseline in electroencephalography (EEG) epileptiform discharges, Change from baseline in seizure frequency, Changes from baseline in Beck Depression Inventory (BDI-II)

Devices

therapeutic

Body systems

Neurology