Study details
Enrolling now
Standard Versus High Dose ED-Initiated Buprenorphine Induction
Yale University
NCT IDNCT06494904ClinicalTrials.gov data as of Apr 2026
Phase
Phase 3
Target enrollment
360
Study length
about 4.1 years
Ages
18–65
Locations
5 sites in CA, ME, NJ +1
What this study is about
Researchers are testing whether a higher dose of buprenorphine, started in the emergency department (ED), helps more people start opioid treatment sooner than a standard dose. The trial will also measure how much withdrawal symptoms and cravings are reduced with both doses.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Take Buprenorphine
Participation Burden
What's physically and logistically required of participants.
Logistics & Travel
In-person visits
Requires travel to a study site
Physical Intervention
Injection / IV
How treatment is administered
Treatment Assignment
Randomized & Blinded
You may get a placebo/standard care, and you won't know which.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
Drug classes
buprenorphine
Drug routes
injection
Body systems
Psychiatry / Mental Health