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Study details
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Relugolix, Enzalutamide, and Radiation Therapy for Very High Risk Prostate Cancer

Northwestern University
NCT IDNCT06499870ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

50

Study length

about 8.2 years

Ages

18+

Sex

Male only

Locations

1 site in IL

What this study is about

This trial is testing whether relugolix and enzalutamide, combined with radiation therapy, are effective in treating very high risk prostate cancer. Relugolix prevents testosterone release to slow tumor growth, while enzalutamide blocks androgen receptors on prostate cells. Radiation therapy uses targeted energy to kill cancer cells.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Fluorine F 18 Piflufolastat
  • 2.Questionnaire Administration
  • 3.Receive Image Guided Radiation Therapy
  • +3 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
OralOral

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

enzalutamide, relugolix

Drug routes

oral (Oral Tablet)

Endpoints

Secondary: Disease-free survival

Procedures

biopsy, diagnostic, imaging, radiation