Skip to content
Study details
Enrolling now

GLP-1R Agonist Treatment for Opioid Use Disorder

Milton S. Hershey Medical Center
NCT IDNCT06548490ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

200

Study length

about 1.9 years

Ages

18–75

Locations

3 sites in MD, NY, PA

What this study is about

Researchers are testing if semaglutide, a medication, can reduce opioid use in adults receiving treatment for opioid use disorder. The trial will compare semaglutide to a placebo (a needle prick with no drug) over 686 days to see if semaglutide helps people refrain from using illicit and nonprescribed opioids.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Placebo
  • 2.Take Semaglutide Pen Injector

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Oral

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

antidiabetic (GLP-1 agonist; stimulates insulin release)

Drug routes

oral (Oral Tablet)

Body systems

Psychiatry / Mental Health