Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents
Phase 1
48
about 3 years
12–24
1 site in CO
What this study is about
Researchers are testing how the body changes after bariatric surgery in adolescents. The trial will investigate why some people respond differently to this surgery and if a medication (semaglutide) can help adolescents who haven't lost enough weight after 1-2 years of bariatric surgery.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Participate in Standard postoperative care
- 2.Receive Injectable semaglutide
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
You are randomly assigned, but you will know your treatment.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
semaglutide (GLP-1 agonist; stimulates insulin release)
oral (Oral Tablet), injection
Primary: Intervention phase: Change in BMI, Observational phase: Change in 24 hour systolic blood pressure (BP), measured by ambulatory BP monitor
Secondary: Change in 24 hour systolic blood pressure (BP), measured by ambulatory BP monitor, Intervention Phase: Number of participants with an adverse event (AE) that leads to discontinuation of the medication, measured by a count, Intervention Phase: Number of participants with at least one serious adverse event (AE) in the active medication group, measured by a count
Endocrinology