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Study details
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Optimization of Pediatric Tonsillectomy to Improve Analgesia

Duke University
NCT IDNCT06576830ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

440

Study length

about 4.5 years

Ages

3–17

Locations

1 site in NC

What this study is about

Researchers are testing whether using short-acting opioids (fentanyl/hydromorphone) or long-acting opioids (methadone) for pain control after tonsillectomy surgery in children and adolescents results in better pain relief. The trial will last 1653 days and involve approximately 440 participants.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Fentanyl/Hydromorphone
  • 2.Take Methadone

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Oral

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

fentanyl, hydromorphone, methadone (Long-acting opioid; prevents withdrawal and reduces craving)

Drug routes

oral (Oral Lozenge)

Endpoints

Secondary: Evaluation of participant's pain as measured by Numeric Pain Rating Scale, Number of participants with adverse event in the PACU (post-anesthesia care unit)