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Study details
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A Phase II Trial of ACR-368 and Low Dose Gemcitabine for Head and Neck Squamous Cell Carcinoma

H. Lee Moffitt Cancer Center and Research Institute
NCT IDNCT06597565ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

43

Study length

about 3.9 years

Ages

18+

Locations

1 site in FL

What this study is about

This trial is testing a treatment combination of ACR-368 and low dose gemcitabine in people with head and neck squamous cell carcinoma. Participants will receive the drugs every 2 weeks until their cancer worsens.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take ACR-368
  • 2.Take Gemcitabine

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IV

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

gemcitabine

Drug routes

injection (Injection)

Endpoints

Primary: Overall Response Rate: Cohort A, Overall Response Rate: Cohort B

Secondary: Duration of response (DOR), Overall Survival (OS), Progression Free Survival (PFS), Safety and Tolerability

Body systems

Oncology