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Study details
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EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis

M.D. Anderson Cancer Center
NCT IDNCT06649058ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

316

Study length

about 5.6 years

Ages

18+

Locations

1 site in TX

What this study is about

This trial is testing if combining stereotactic radiosurgery (SRS) with systemic therapy can help control brain metastases in patients who have a partial response or stable brain metastases after receiving systemic treatment. The goal is to see if SRS helps manage the disease better than treating only worsening metastases, especially when systemic therapy isn't enough.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Participate in Systemic Therapy
  • 2.Receive Stereotactic Radiosurgery

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: Safety and Adverse Events (AEs).

Procedures

radiation