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Study details
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A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)

Eli Lilly and Company
NCT IDNCT06657768ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

88

Study length

about 2.8 years

Ages

45–85

Locations

7 sites in CA, FL, GA +2

What this study is about

This trial is testing the safety and tolerability of a drug called LY4006895. Part A will give healthy people a single dose, while Part B will give participants with early Alzheimer's disease multiple doses. Blood tests will be done to see how much of the drug gets into the body and how long it stays there.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take LY4006895
  • 2.Take Placebo

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs), Serious Adverse Event(s) (SAEs), and Discontinuations due to Adverse Event(s) (AEs) Considered by the Investigator to be Related to Study Drug Administration

Secondary: PK: Area Under the Concentration Versus Time Curve (AUC) of LY4006895, PK: Maximum Concentration (Cmax) of LY4006895

Body systems

Neurology