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Study details
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XALute Trial

Amgen
NCT IDNCT06691984ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

675

Study length

about 4.6 years

Ages

18+

Sex

Male only

Locations

42 sites in AL, CA, FL +20

What this study is about

Researchers are testing whether xaluritamig, compared to cabazitaxel or another treatment for prostate cancer, helps people live longer. The trial will last about 1694 days and involve approximately 675 participants.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Abiraterone
  • 2.Take Cabazitaxel
  • 3.Take Enzalutamide
  • +1 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IVInjection / IV

How treatment is administered

Treatment Assignment
Randomized (Open Label)

You are randomly assigned, but you will know your treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

abiraterone, cabazitaxel, enzalutamide

Drug routes

injection, intravenous, oral (Oral Tablet)

Endpoints

Primary: Overall Survival (OS)

Secondary: Area Under the Concentration-time Curve (AUC) of Xaluritamig, Change from Baseline in BPI-SF Pain Intensity Scale Score, Change from Baseline in BPI-SF Pain Interference Scale Score, Change from Baseline in Brief Pain Inventory - Short Form (BPI-SF) Worst Pain Score, Change from Baseline in Functional Assessment of Cancer Therapy - Prostate (FACT-P) Total Score and Subscale Score, Change from baseline in the EQ-5D-5L Visual Analogue Scale (VAS), Change from baseline in the European Quality of Life 5 Domain 5 Level Scale (EQ-5D-5L) Utility Score, Disease Control Rate per Modified RECIST v1.1 as Assessed by BICR

Body systems

Oncology