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Study details
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A Study of Lorigerlimab in Participants With Advanced Solid Tumors

MacroGenics
NCT IDNCT06730347ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

60

Study length

about 2.3 years

Ages

18+

Sex

Female only

Locations

7 sites in CA, LA, MI +3

What this study is about

Researchers are testing lorigerlimab, a medication, in people with advanced solid tumors. The trial will last for 852 days and involve approximately 60 participants who are female only. Participants will receive lorigerlimab by IV infusion every 21 days until cancer progresses or unacceptable side effects occur.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive Lorigerlimab

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IV

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

monoclonal antibody

Drug routes

intravenous

Endpoints

Primary: Objective Response Rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria as determined by the investigator

Secondary: Best percent change from baseline in tumor size, Disease control rate (DCR), Frequency and severity of adverse events (AEs), serious AEs (SAEs), immune-related AEs (irAEs), and AEs leading to dose modifications or treatment discontinuation., Median duration of response (DoR) per RECIST 1.1 criteria, Median progression free survival (PFS) per RECIST 1.1 criteria, Percent change from baseline in tumor size

Body systems

Oncology, Reproductive Health