Study details
Enrolling now
Psilocybin on Brain Mechanisms of Motivation in OUD
Anna Rose Childress, Ph.D.
NCT IDNCT06810310ClinicalTrials.gov data as of Apr 2026
Phase
Phase 2
Target enrollment
24
Study length
about 4 months
Ages
18–60
Locations
1 site in PA
What this study is about
This trial is testing whether psilocybin affects brain circuits related to motivation and addiction in people with opioid use disorder. Participants will receive either a low or high dose of psilocybin, followed by assessments using fMRI to examine brain activity before and after treatment.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Take Psilocybin (high dose)
- 2.Take psilocybin (low dose)
Participation Burden
What's physically and logistically required of participants.
Logistics & Travel
In-person visits
Requires travel to a study site
Physical Intervention
Oral
How treatment is administered
Treatment Assignment
Randomized & Blinded
You may get a placebo/standard care, and you won't know which.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
Drug routes
oral
Body systems
Psychiatry / Mental Health