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Study details
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A Study to Evaluate the Impact of Mosunetuzumab Consolidation for Older Patients With Diffuse Large B-cell Lymphoma (DLBCL) Who Have Detectable Amounts of ctDNA (Circulating Tumor DNA) at the End of Treatment With Pola-R-mini-CHP

Danielle Wallace
NCT IDNCT06828991ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

40

Study length

about 4.7 years

Ages

70+

Locations

1 site in NY

What this study is about

This trial is testing whether adding mosunetuzumab to treatment can help older patients with DLBCL who have detectable ctDNA in their blood. The goal is to see if this approach leads to better disease control and outcomes for these patients, as well as assess the safety of this regimen.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Mosunetuzumab
  • 2.Use ClonoSEQ

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

mosunetuzumab

Endpoints

Primary: ctDNA clearance rate after mosunetuzumab treatment

Secondary: Objective response rate and complete response rate of pola-R-mini-CHP